An Aggregation-Induced Polymerization Poly(Disulfide)-Drug Nanoplatform for Autoimmune Uveitis Therapy via…

Animal / preclinicalAdvanced science (Weinheim, Baden-Wurttemberg, Germany)· Jul 2026

An Aggregation-Induced Polymerization Poly(Disulfide)-Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS-STING Pathway.

Yuelan Wu, Wenbo Geng, Qinjin Dai … Peizeng Yang

UveitisAnimal / preclinicalQ1IF 14.1

New nanoplatform crossed the blood-retinal barrier far better than the free drug alone.

An Aggregation-Induced Polymerization Poly(Disulfide)-Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS-STING Pathway.

Yuelan Wu … Peizeng Yang

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Jul 2026 · Q1 in General Medicine

Background

Autoimmune uveitis is a sight-threatening inflammatory disease in which the cGAS-STING signaling pathway exacerbates inflammation by recognizing excessive cell-free DNA (cfDNA).

Results

5.09-fold

the new nanoplatform crossed into the eye's retina far more easily than the plain drug

More results

This platform is designed to synergistically inhibit the cGAS-STING pathway and achieve efficient intraocular drug delivery.

LA/dexamethasone phosphate functioned as an efficient scavenger of cfDNA through electrostatic interaction, thereby inhibiting cGAS-STING overactivation.

More results

In an experimental autoimmune uveitis mouse model, LA/dexamethasone phosphate treatment significantly reduced cfDNA levels and inhibited cGAS-STING signaling.

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Conclusion

In summary, this study establishes a highly barrier-permeable nanoplatform that synergistically integrates drug delivery with cGAS-STING pathway inhibition, offering a promising therapeutic strategy for autoimmune uveitis.

An Aggregation-Induced Polymerization Poly(Disulfide)-Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS-STING Pathway.

An Aggregation-Induced Polymerization Poly(Disulfide)-Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS-STING Pathway.

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