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New research · Ophthalmology
Ocular immunology and inflammation · 4d
Cohort studyOcular immunology and inflammation · 2026

Consecutive Dexamethasone-Fluocinolone Acetonide Therapy in Non-Infectious Uveitic Macular Edema: Real-World Outcomes.

Aydin Özen, Nicole Stübiger, Carsten Grohmann … Johannes Birtel
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OphthalmologyCohort study

Fluocinolone acetonide implant gave long-lasting control after dexamethasone in uveitic macular edema.

Consecutive Dexamethasone-Fluocinolone Acetonide Therapy in Non-Infectious Uveitic Macular Edema: Real-World Outcomes.

Aydin Özen … Johannes Birtel
Ocular immunology and inflammation · 2026
Purpose

To evaluate the efficacy and durability including a consecutive intravitreal corticosteroid treatment strategy involving dexamethasone (dexamethasone) followed by fluocinolone acetonide (fluocinolone acetonide), in non-infectious uveitis with macular edema (uveitis with macular edema).

Methods

This real-world study included 80 eyes from 62 patients, receiving a total of 164 intravitreal injections (124 dexamethasone and 40 fluocinolone acetonide).

n = 80 eyes
35
Results
35
months
typical time before repeat treatment was needed to control swelling again
n = 80 eyes
More results

Dexamethasone implantation resulted in rapid and significant improvements in BCVA and central macular thickness, with peak effects observed at approximately 4 weeks; however, anatomical benefits were often time-limited, necessitating reinjection.

More results

Eyes receiving dexamethasone followed by fluocinolone acetonide achieved effective long-term disease control and a reduced treatment burden.

Adverse events, including intraocular pressure elevations, were transient and manageable.

“
Conclusion

A consecutive DEX-to-FAc treatment strategy offers sustained disease control and may reduce treatment burden in patients with chronic disease.

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