Health Status Outcomes 7 Years After Transcatheter or Surgical Aortic Valve Replacement in Low-Surgical Risk Patients With Aortic Stenosis.
Transcatheter aortic valve replacement led to substantially better health status at 1 month.
Health Status Outcomes 7 Years After Transcatheter or Surgical Aortic Valve Replacement in Low-Surgical Risk Patients With Aortic Stenosis.
Transcatheter aortic valve replacement (transcatheter aortic valve replacement) results in early improvements in health status outcomes relative to surgical aortic valve replacement (surgical aortic valve replacement) in low-surgical risk patients with symptomatic severe aortic stenosis.
The purpose of this study was to compare long-term health status outcomes between transcatheter aortic valve replacement and surgical aortic valve replacement in low-risk patients and explore heterogeneity of treatment effect.
The PARTNER 3 (Placement of Aortic Transcatheter Valves) trial randomized patients with severe aortic stenosis and low surgical risk 1:1 to transcatheter aortic valve replacement with a balloon-expandable valve vs surgical aortic valve replacement.
transcatheter aortic valve replacement led to substantially better health status at 1 month
The analytic cohort included 943 patients enrolled in the PARTNER 3 trial who had baseline Kansas City Cardiomyopathy Questionnaire assessments and underwent their assigned procedure (494 transcatheter aortic valve replacement, 449 surgical aortic valve replacement; mean age: 73.5 ± 5.9 years; 69.2% men; mean Society of Thoracic Surgeons-Predicted Risk of Mortality: 1.9% ± 0.6%; mean Kansas City Cardiomyopathy Questionnaire-overall summary [Kansas City Cardiomyopathy Questionnaire-OS] score: 70.9 ± 20.5).
Transcatheter aortic valve replacement and surgical aortic valve replacement both resulted in significant improvements in Kansas City Cardiomyopathy Questionnaire and Short Form-36 Heath Survey summary scores relative to baseline through 7-year follow-up.
Patients with severe aortic stenosis at low surgical risk had substantial improvement in patient-reported health status with either transcatheter aortic valve replacement or surgical aortic valve replacement that was sustained through 7 years.
Patients had earlier recovery with transcatheter aortic valve replacement, but health status outcomes after 2 years were similar between treatment groups.
(PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis; NCT02675114).