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Cohort studyBritish journal of hospital medicine (London, England : 2005) · 2026

Platelet-To-Lactate Ratio Predicts In-Hospital Mortality in Patients With Sepsis-Induced Coagulopathy: A Retrospective Cohort Study.

Shuai Mao, Xuan Zhang, Shengshu Wang … Tong Yin

Pulmonology & Critical CareCohort study

Lowest platelet-to-lactate ratio is associated with higher mortality in sepsis-induced coagulopathy.

Platelet-To-Lactate Ratio Predicts In-Hospital Mortality in Patients With Sepsis-Induced Coagulopathy: A Retrospective Cohort Study.

Shuai Mao … Tong Yin

British journal of hospital medicine (London, England : 2005) · 2026

Background

Sepsis-induced coagulopathy (sepsis-induced coagulopathy) is a life-threatening complication with high mortality.

Purpose

Sepsis-induced coagulopathy (sepsis-induced coagulopathy) is a life-threatening complication with high mortality.

Methods

This retrospective cohort study included patients with sepsis-induced coagulopathy who were diagnosed after admission to the intensive care unit (intensive care unit) of Chinese PLA General Hospital between December 2017 and October 2025.

n = 1722 patients

Results

lowest platelet-to-lactate ratio was associated with 3.5 times higher risk of dying

AUC 0.71 (95% CI 0.68 to 0.74)

CI excludes the null - significant

More results

Among 1722 patients with sepsis-induced coagulopathy, the in-hospital mortality was 26.2% (n = 452).

Restricted cubic spline analysis revealed a threshold effect at PLAC = 28.

More results

The area under the curve (AUC) for the PLAC was 0.711 (95% CI: 0.683-0.738), which was comparable to that of the Sequential Organ Failure Assessment score ( p = 0.135) and superior to that of the sepsis-induced coagulopathy score and Charlson comorbidity index score (both p < 0.001).

“

Conclusion · 1 of 2

The PLAC is independently associated with in-hospital mortality in patients with sepsis-induced coagulopathy, with a clinically actionable threshold of 28.

Conclusion · 2 of 2

The PLAC is a simple biomarker that integrates coagulation and perfusion status and is a practical tool for risk stratification. However, multicenter prospective studies are needed to validate these findings.

Post

Platelet-To-Lactate Ratio Predicts In-Hospital Mortality in Patients With Sepsis-Induced Coagulopathy: A Retrospective Cohort Study.

Lowest platelet-to-lactate ratio is associated with higher mortality in sepsis-induced coagulopathy.

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