Barrett's esophagus around the world: a systematic review and predictive modeling study.

Studies requiring histologic confirmation of intestinal metaplasia reported lower estimates than those using broader definitions.

Significant heterogeneity was observed by region and publication period.

Seattle biopsy protocol reporting was documented in 38.5% of studies and improved after 2010.

Forecast models projected BE prevalence of 12.8-13.2% by 2050 using linear modeling and 11.2-11.8% using GAM.