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New research · Gastroenterology
Gastroenterology and hepatology from bed to bench · 4d
ReviewGastroenterology and hepatology from bed to bench · 2026

Barrett's esophagus around the world: a systematic review and predictive modeling study.

Amirhossein Hajialigol, Bennaz Nouri, Navid Emamhassani … Mohsen Rajabnia
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GastroenterologyReview

The global pooled mean prevalence of Barrett's esophagus is 5.76%.

Barrett's esophagus around the world: a systematic review and predictive modeling study.

Amirhossein Hajialigol … Mohsen Rajabnia
Gastroenterology and hepatology from bed to bench · 2026
Background

Accurate BE prevalence estimates are essential for developing effective screening and surveillance strategies.

Purpose

This study aimed to synthesize evidence on the prevalence of Barrett's esophagus (BE), estimate its global burden, and examine variation across studies.

Methods

A systematic search was conducted in PubMed, Scopus, Web of Science, and EMBASE from inception to January 2026.

n = approximately 8.4 million
5.76%
Results
5.76%
The average prevalence of Barrett's esophagus across studies was 5.76%.
n = approximately 8.4 million
More results

Studies requiring histologic confirmation of intestinal metaplasia reported lower estimates than those using broader definitions.

Significant heterogeneity was observed by region and publication period.

Seattle biopsy protocol reporting was documented in 38.5% of studies and improved after 2010.

More results

Forecast models projected BE prevalence of 12.8-13.2% by 2050 using linear modeling and 11.2-11.8% using GAM.

“
Conclusion · 1 of 2

Reported BE prevalence varies widely, mainly due to differences in diagnostic criteria, study populations, and methodology.

Conclusion · 2 of 2

Standardized definitions, biopsy protocols, and reporting practices are needed to improve epidemiologic accuracy and guide screening.

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