A multi-national study examined the response sustainability to calcineurin inhibitors and long-term kidney survivals in children with genetic podocytopathies.

At least partial response was attained in 28% and 22% of patients at six months post-calcineurin inhibitors initiation and last follow-up, respectively.

Compared to non-response group, patients with at least partial response at six months had significantly lower urine protein-to-creatinine ratios across various timepoints post-calcineurin inhibitors.

71%, 11% and 18% exhibited no response, non-sustained and sustained response, respectively, throughout the observation period.

Both sustained and non-sustained responses were significantly associated with superior kidney survival compared to no response.