dNLR, NLR, and NMLR as differential markers for assessing severity and sepsis in emphysematous pyelonephritis.
NMLR is associated with identifying sepsis in emphysematous pyelonephritis.
dNLR, NLR, and NMLR as differential markers for assessing severity and sepsis in emphysematous pyelonephritis.
This study aims to evaluate the association between blood count-derived inflammatory markers and the severity of radiographic disease, as well as the presence of sepsis in patients with Emphysematous pyelonephritis.
This retrospective cohort study included 47 adult patients diagnosed with EPN.
The NMLR score's diagnostic accuracy for identifying sepsis was 0.683.
The derived neutrophil-to-lymphocyte ratio (dNLR) had a statistically significant association with Huang's CT classification ( H = 9.555, p = 0.023), with median values increasing with severity grade.
In sepsis, both NLR and NMLR levels were considerably higher ( p = 0.041 and p = 0.033, respectively).
However, none CBC-derived inflammatory markers were related to long-term unfavorable outcomes (death or permanent dialysis), which were robustly predicted by traditional renal function markers (creatinine and cystatin C; all p < 0.05).
dNLR, NLR, and NMLR are readily obtainable CBC-derived indicators that show distinct clinical associations in EPN.
dNLR correlates with anatomical disease severity, while NLR and NMLR are superior indicators for identifying concomitant sepsis.
These inexpensive markers offer practical, complementary tools for acute-phase risk stratification, aiding in the timely recognition of severe disease and systemic complications.