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New research · Endocrinology
Gut · 4d
Cohort studyGut · 2026

Impact of initial severity and progression pattern of new-onset diabetes on pancreatic cancer risk: a 15-year longitudinal nationwide cohort study.

Minyoung Lee, Min Heui Yu, Wonjeong Chae … Moon Jae Chung
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EndocrinologyCohort study

Higher initial antidiabetic treatment intensity is associated with increased pancreatic cancer risk.

Impact of initial severity and progression pattern of new-onset diabetes on pancreatic cancer risk: a 15-year longitudinal nationwide cohort study.

Minyoung Lee … Moon Jae Chung
Gut · 2026
Background

New-onset diabetes (new-onset diabetes) increases the risk of pancreatic cancer.

Purpose

This 15-year longitudinal nationwide cohort study aimed to analyse the pancreatic cancer risk based on the initial severity and progression pattern of new-onset diabetes.

Methods

We included 402 663 individuals with or without new-onset diabetes from the Korean National Health Insurance Service (2005-2019).

n = 663 individuals
5.60
Results
5.60
New-onset diabetes patients on insulin had 5.60 times higher hazard of pancreatic cancer.
n = 663 individuals
More results

Within the same baseline treatment-intensity category, individuals with rapid escalation within 6 months had a higher risk of pancreatic cancer than those with stable or decreased treatment intensity.

More results

In some comparisons between groups with different baseline treatment intensities, the risk of pancreatic cancer was higher with less intensive baseline therapy but subsequent intensification than with more intensive baseline therapy without progression.

“
Conclusion

Greater initial severity of new-onset diabetes and rapid early aggravation were both associated with an increased risk of pancreatic cancer.

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