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New research · Endocrinology
Journal of nutrition and metabolism · 4d
Randomized trialJournal of nutrition and metabolism · 2026

An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.

Naser Aghamohammadzadeh, Mojgan Abdi Oskoui, Neda Dolatkhah, Azizeh Farshbaf Khalili
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EndocrinologyRandomized trial

Cosupplementation reduced systemic inflammation in elderly patients with type 2 diabetes.

An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.

Naser Aghamohammadzadeh … Azizeh Farshbaf Khalili
Journal of nutrition and metabolism · 2026
Purpose

This study aimed to evaluate the effects of cosupplementation with high-dose vitamin D3 and flaxseed oil on inflammatory markers, oxidative stress, and metabolic health in elderly patients with T2DM.

Methods

We conducted an 8-week, triple-blind, randomized, placebo-controlled clinical trial in Iran, enrolling 104 elderly patients with T2DM, of whom 102 completed the study.

n = 104 elderly patients with T2DM
Results
MD: -0.98 μg/mL
the supplement combination significantly lowered systemic inflammation
n = 104 elderly patients with T2DM
More results

Physical health-related quality of life, including pain scores and physical functioning, also improved significantly ( p < 0.05).

The intervention was well tolerated with minimal adverse events.

“
Conclusion · 1 of 3

Cosupplementation with flaxseed oil and high-dose vitamin D 3 significantly reduced systemic inflammation in elderly patients with T2DM.

Conclusion · 2 of 3

Exploratory findings further suggest potential benefits for oxidative stress, glycemic control, lipid profile, and physical quality of life, warranting confirmation in future trials.

Conclusion · 3 of 3

Trial Registration: Iranian Clinical Trials Register: IRCT20161022030424N8.

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