Anisometropia and Its Related Traits: Ocular, Systemic, and Genetic Characteristics-Results From the Gutenberg Health Study.

The median axial length difference between both eyes was 0.12 mm (range, 0-8.11 mm).

Age (odds ratio [OR], 1.01; 95% CI, 1.01-1.02; P < 0.001) and years of education (OR, 1.06; 95% CI, 1.03-1.08; P < 0.001) were associated with anisometropia of ≥1 D.

Female sex was inversely associated with hyperopic anisometropia of ≥1 D (OR, 0.77; 95% CI, 0.62-0.96; P = 0.02).

Genome-wide association study on intereye difference in axial length revealed a significant (P < 5 × 10-8) association of 10 single nucleotide polymorphisms at the intron of DNAH5.