Physicochemical stability and protein corona profiling on the interaction of iron oxide nanoparticles with…

StudyJournal of materials chemistry. B· Jul 2026

Physicochemical stability and protein corona profiling on the interaction of iron oxide nanoparticles with human tears.

Bhagyasree Paila, Sneha Asok, Anil K Suresh

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25 tear proteins stick to iron oxide nanoparticles, forming a protein coating

Physicochemical stability and protein corona profiling on the interaction of iron oxide nanoparticles with human tears.

Bhagyasree Paila … Anil K Suresh

Journal of materials chemistry · Jul 2026 · Q1 in General Medicine

Background

The integration of nanotechnology into ophthalmology represents a promising frontier for the development of precision diagnostics and therapeutics aimed at enhancing ocular health.

Results

25

25 tear proteins stuck to the nanoparticle surface, forming a coating

More results

Dynamic light scattering (dynamic light scattering) revealed a modest increase in hydrodynamic diameter from ∼115 ± 3.3 nm to ∼139 ± 0.7 nm, accompanied by a reduction in the zeta potential (zeta potential) from ∼-36 ± 1.7 mV to ∼-29 ± 1 mV, likely due to protein adsorption.

More results

These findings provide protein dynamics of the ocular nano-bio interface, emphasizing the influence of tear protein composition on iron oxide nanoparticles.

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Conclusion

Our results highlight how tear protein corona formation defines the physicochemical stability of iron oxide nanoparticles within the human tear environment and provide a basic understanding of these alterations, which may influence iron oxide nanoparticles-based ocular therapeutic systems.

Physicochemical stability and protein corona profiling on the interaction of iron oxide nanoparticles with human tears.

Physicochemical stability and protein corona profiling on the interaction of iron oxide nanoparticles with human tears.

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