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StudyJournal of materials chemistry. B · 2026

Physicochemical stability and protein corona profiling on the interaction of iron oxide nanoparticles with human tears.

Bhagyasree Paila, Sneha Asok, Anil K Suresh

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OphthalmologyStudy

25 tear proteins stick to iron oxide nanoparticles, forming a protein coating

Physicochemical stability and protein corona profiling on the interaction of iron oxide nanoparticles with human tears.

Bhagyasree Paila … Anil K Suresh

Journal of materials chemistry. B · 2026

Background

The integration of nanotechnology into ophthalmology represents a promising frontier for the development of precision diagnostics and therapeutics aimed at enhancing ocular health.

Results

25

25 tear proteins stuck to the nanoparticle surface, forming a coating

More results

Dynamic light scattering (dynamic light scattering) revealed a modest increase in hydrodynamic diameter from ∼115 ± 3.3 nm to ∼139 ± 0.7 nm, accompanied by a reduction in the zeta potential (zeta potential) from ∼-36 ± 1.7 mV to ∼-29 ± 1 mV, likely due to protein adsorption.

More results

These findings provide protein dynamics of the ocular nano-bio interface, emphasizing the influence of tear protein composition on iron oxide nanoparticles.

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Conclusion

Our results highlight how tear protein corona formation defines the physicochemical stability of iron oxide nanoparticles within the human tear environment and provide a basic understanding of these alterations, which may influence iron oxide nanoparticles-based ocular therapeutic systems.

Post

Physicochemical stability and protein corona profiling on the interaction of iron oxide nanoparticles with human tears.

25 tear proteins stick to iron oxide nanoparticles, forming a protein coating

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