Statin use associated with smaller cup-to-disc ratio in glaucoma patients of African ancestry
Statin Use and Primary Open-Angle Glaucoma Severity in Patients of African Ancestry.
Joan O'Brien … Gui-Shuang Ying
Research square · 2026
Purpose
This study examines the association of statins with the prevalence and severity of primary open-angle glaucoma in this ancestry group.
Methods
SUBJECTS: 5715 subjects of African ancestry (African American, African descent, or African Caribbean) ages 35 and older, recruited from ophthalmology clinics in the University of Pennsylvania Health System as part of the Primary Open-Angle African Ancestry Glaucoma Genetics (POAAGG) study.
n = 5715 subjects
Results
statin users had slightly less optic nerve damage
MD by subgroup · 95% CI
More results
Primary open-angle glaucoma prevalence did not differ between statin users and non-users (OR: 0.99,95% CI: 0.85,1.14; p = 0.84).
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Conclusion · 1 of 2
Statin use was not associated with primary open-angle glaucoma prevalence but was associated with milder structural and functional disease features among cases.
Conclusion · 2 of 2
These findings suggest the need for further investigation of the effect of statins in African ancestry patients with primary open-angle glaucoma.