Lower frailty scores are associated with lower corneal resistance in glaucoma patients.
Association Between Geriatric Assessment Scores and Corneal Biomechanical Parameters in Patients with Glaucoma.
Yuto Yoshida … Masaki Tanito
Biomedicines · 2026
Background
Multiple age-related systemic conditions, including frailty, cognitive impairment, and comorbid diseases, have been suggested to be associated with glaucoma.
Methods
This retrospective cross-sectional study included patients with glaucoma who attended the Department of Ophthalmology at Shimane University Hospital between May 2019 and August 2024.
n = 456 eyes
Results
Lower Geriatric 8 scores are associated with lower corneal resistance factor.
β 0.18 (95% CI 0.05 to 0.30)
null 0
0.05
0.30
CI excludes the null - significant
More results
The mean age was 70.2 ± 11.1 years, and 126 patients (45.0%) were women.
In contrast, no significant association was observed between G8 scores and corneal hysteresis (β = -0.02,95% CI: -0.12 to 0.09).
Neither Mini-Cog nor Charlson Comorbidity Index was significantly associated with any ocular parameters.
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Conclusion
In patients with glaucoma, frailty may be associated with corneal biomechanical properties, particularly corneal resistance factor and intraocular pressure-related parameters.