Nose-to-Eye Delivery: The Potential of Intranasal Administration in Ophthalmology. | ScholarDeck

Paper

Nose-to-Eye Delivery: The Potential of Intranasal Administration in Ophthalmology.

New research · Ophthalmology

Journal of clinical medicine · 3mo

ReviewJournal of clinical medicine· Jun 2026

Nose-to-Eye Delivery: The Potential of Intranasal Administration in Ophthalmology.

Maria Letizia Adezio, Danilo Iannetta, Gianluca Manni … Ludovico Alisi

Read paper

GlaucomaReviewQ2IF 3.5

Conventional eye drops provide very low drug delivery to the eye.

Nose-to-Eye Delivery: The Potential of Intranasal Administration in Ophthalmology.

Maria Letizia Adezio … Ludovico Alisi

Journal of clinical medicine · Jun 2026 · Q2 in General Medicine

Purpose

This review explores the intranasal (intranasal) route as a promising strategy for targeting both the anterior and posterior segments of the eye.

less than 5%

Results

less than 5%

very little medicine from eye drops actually reaches the eye

More results

Pre-clinical evidence indicates that intranasal administration of agents such as erythropoietin, nerve growth factor, and insulin achieves superior retinal concentrations compared to topical or systemic dosing, offering neuroprotection in models of retinal degeneration and glaucoma.

“

Conclusion

Future advancements in mucoadhesive nanocarriers are essential to optimize drug residence time and realize the full potential of nose-to-eye delivery in chronic ophthalmic care.

Read paper