Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the…

StudyActa ophthalmologica· Feb 2011

Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the combination of morning dosing of bimatoprost and dorzolamide hydrochloride.

Andrzej Stankiewicz, Marta Misiuk-Hojło, Iwona Grabska-Liberek … Alon Harris

GlaucomaStudyTreatmentQ1IF 3.0

Added dorzolamide was associated with lower mean diurnal intraocular pressure.

Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the combination of morning dosing of bimatoprost and dorzolamide hydrochloride.

Andrzej Stankiewicz … Alon Harris

Acta ophthalmologica · Feb 2011 · Q1 in Ophthalmology

Purpose

This prospective, multicenter, single-masked study evaluated the additive effect of dorzolamide hydrochloride 2% on the diurnal intraocular pressure (IOP) curve and retinal and retrobulbar hemodynamics in patients with primary open-angle glaucoma (primary open-angle glaucoma) treated with morning-dosed bimatoprost 0.03%.

Methods

Eighty-nine patients (aged, 60.7 ± 11.8 years, range 33-80; 68 women) with primary open-angle glaucoma received bimatoprost dosed once in the morning for 1 month, after which dorzolamide was added twice daily for 2 months.

n = 68 women

Results

lower pressure inside the eye after dorzolamide was added

12.9mmHg

dorzolamide adjunctive

13.6mmHg

bimatoprost monotherap

More results

Mean baseline IOP was 16.5 ± 3.4 mmHg.

Adjunctive dorzolamide therapy significantly decreased vascular resistance in the ophthalmic artery (p = 0.02).

Mean diastolic blood pressure and ocular perfusion pressures were significantly lower after adjunctive therapy.

There were no changes in retinal microcirculation between the two phases of treatment.

“

Conclusion

Adjunctive dorzolamide therapy to morning-dosed bimatoprost 0.03% reduced diurnal IOP and vascular resistance in the ophthalmic artery but did not alter retinal circulation in this group of patients with primary open-angle glaucoma.

Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the combination of morning dosing of bimatoprost and dorzolamide hydrochloride.

Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the combination of morning dosing of bimatoprost and dorzolamide hydrochloride.

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