Post

Rita Ehrlich
Acta ophthalmologica
15y
StudyActa ophthalmologica · 2011

Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the combination of morning dosing of bimatoprost and dorzolamide hydrochloride.

Andrzej Stankiewicz, Marta Misiuk-Hojło, Iwona Grabska-Liberek … Alon Harris
Read paper
OphthalmologyStudy

Added dorzolamide was associated with lower mean diurnal intraocular pressure.

Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the combination of morning dosing of bimatoprost and dorzolamide hydrochloride.

Andrzej Stankiewicz … Alon Harris
Acta ophthalmologica · 2011
Purpose

This prospective, multicenter, single-masked study evaluated the additive effect of dorzolamide hydrochloride 2% on the diurnal intraocular pressure (IOP) curve and retinal and retrobulbar hemodynamics in patients with primary open-angle glaucoma (primary open-angle glaucoma) treated with morning-dosed bimatoprost 0.03%.

Methods

Eighty-nine patients (aged, 60.7 ± 11.8 years, range 33-80; 68 women) with primary open-angle glaucoma received bimatoprost dosed once in the morning for 1 month, after which dorzolamide was added twice daily for 2 months.

n = 68 women
Results

lower pressure inside the eye after dorzolamide was added

12.9mmHg
dorzolamide adjunctive
13.6mmHg
bimatoprost monotherap
More results

Mean baseline IOP was 16.5 ± 3.4 mmHg.

Adjunctive dorzolamide therapy significantly decreased vascular resistance in the ophthalmic artery (p = 0.02).

Mean diastolic blood pressure and ocular perfusion pressures were significantly lower after adjunctive therapy.

There were no changes in retinal microcirculation between the two phases of treatment.

“
Conclusion

Adjunctive dorzolamide therapy to morning-dosed bimatoprost 0.03% reduced diurnal IOP and vascular resistance in the ophthalmic artery but did not alter retinal circulation in this group of patients with primary open-angle glaucoma.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cross-sectional
44.1%
had too much homocysteine in the blood, a far larger share than in dry AMD or healthy eyes
Cohort Study
92.3%
most laser-treated eyes had a favorable eye-structure outcome
Cohort Study
56%
lost three or more lines on the eye-chart vision test
Cohort Study
50%
older patients were more likely to lose three or more lines of vision
Study
81%
trials where mask air leaks were detected blowing toward the eyes
Cohort Study
13.5%
Central retinal artery peak blood-flow speed was 13.5% lower in diabetic patients.
Study
379 +/- 156 microm
lower thickness in the central retina, checked with an eye scan
Case Report
9 of 10 eyes
eyes had better measured vision after treatment