Photodynamic therapy for occult choroidal neovascularization with pigment epithelium detachment in…

Cohort studyArchives of ophthalmology (Chicago, Ill. : 1960)· Apr 2004

Photodynamic therapy for occult choroidal neovascularization with pigment epithelium detachment in age-related macular degeneration.

Ruth Axer-Siegel, Rita Ehrlich, Irit Rosenblatt … Dov Weinberger

RetinaCohort studyTreatment

After photodynamic therapy, 56% of eyes lost three or more visual-acuity lines.

Photodynamic therapy for occult choroidal neovascularization with pigment epithelium detachment in age-related macular degeneration.

Ruth Axer-Siegel … Dov Weinberger

Archives of ophthalmology (Chicago, Ill. · Apr 2004

Purpose

To study the visual and angiographic outcome of eyes with neovascular age-related macular degeneration associated with pigment epithelium detachment (pigment epithelium detachment) treated by photodynamic therapy.

Methods

Review of the medical charts and the fluorescein and indocyanine green angiograms of all consecutive patients with age-related macular degeneration associated with choroidal neovascularization and serous pigment epithelium detachment of at least 1 disc diameter, who received photodynamic therapy from January 1, 2000, to August 31, 2002.

n = 34 eyes

Results

lost three or more lines on the eye-chart vision test

56%

lost 3 or more Snellen

21%

lost 1 or 2 lines

18%

maintained their initi

6%

gained 1 or 2 lines

More results

Thirty patients (34 eyes) met the study criteria.

Subretinal hemorrhage occurred in 5 eyes and retinal pigment epithelium tears in 4 eyes.

In 4 eyes, visual acuity decreased to counting fingers, hand motions, or light perception.

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Conclusion · 1 of 2

Although 44% of the 34 eyes with age-related macular degeneration and pigment epithelium detachment lost fewer than 3 Snellen lines in acuity, severe visual loss to counting fingers or less occurred in 4 eyes, 3 of them with choroidal neovascularization inside the pigment epithelium detachment.

Conclusion · 2 of 2

Further studies and treatment modalities are required to improve prognosis of neovascular age-related macular degeneration with serous pigment epithelium detachment.

Photodynamic therapy for occult choroidal neovascularization with pigment epithelium detachment in age-related macular degeneration.

Photodynamic therapy for occult choroidal neovascularization with pigment epithelium detachment in age-related macular degeneration.

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