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New research · Internal Medicine
European journal of trauma and emergency surgery : official publication of the European Trauma Society · 1w
Cohort studyEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026

Elevated risk of wound and systemic complications in MRSA-colonized patients undergoing lower extremity orthopedic trauma surgery.

Aruni S Areti, Harris Hafeez, Pradyun V Sangineni … Jack Dawson
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Internal MedicineCohort study

Methicillin-resistant Staphylococcus aureus colonization before lower-limb trauma surgery is linked to higher odds of sepsis

Elevated risk of wound and systemic complications in MRSA-colonized patients undergoing lower extremity orthopedic trauma surgery.

Aruni S Areti … Jack Dawson
European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
Background

Preoperative colonization with methicillin-resistant Staphylococcus aureus (methicillin-resistant Staphylococcus aureus) is a known risk factor for adverse outcomes in arthroplasty but remains under-investigated in orthopedic trauma.

Purpose

This study evaluates the impact of preoperative methicillin-resistant Staphylococcus aureus colonization on postoperative complication rates in patients undergoing lower extremity orthopedic trauma surgery.

Methods

With a documented methicillin-resistant Staphylococcus aureus diagnosis within three months before surgery were matched 1:1 to methicillin-resistant Staphylococcus aureus-negative controls based on demographics and comorbidities.

n = 629,342 control
Results

far higher odds of sepsis, a dangerous body-wide reaction to infection

Sepsis
3.71OR
Pulmonary embolism
2.8OR
Pneumonia
2.33OR
DVT
2.29OR
More results

A total of 1,868 methicillin-resistant Staphylococcus aureus+ and 629,342 control patients were identified.

No significant differences in surgical site infections were observed after matching.

“
Conclusion · 1 of 3

Preoperative methicillin-resistant Staphylococcus aureus colonization is associated with increased risks of wound dehiscence, pneumonia, sepsis, thromboembolic events, blood transfusions, and acute renal failure in orthopedic trauma patients.

Conclusion · 2 of 3

Preoperative methicillin-resistant Staphylococcus aureus screening may serve as a risk-stratification tool, enabling surgeons to anticipate systemic complications and optimize management.

Conclusion · 3 of 3

Where feasible, screening with targeted decolonization or prophylactic strategies may mitigate risk.

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