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Cohort studyPediatric surgery international · 2026

Transfer learning prediction of 2-year native liver survival in biliary atresia following Kasai portoenterostomy using early perioperative biochemical data up to 3 months postoperatively.

Chuanping Xie, Wenqing Yan, Yong Zhao … Jinshi Huang

AI in MedicineCohort study

Transfer-learning model predicted 2-year native liver survival after Kasai portoenterostomy for biliary atresia

Transfer learning prediction of 2-year native liver survival in biliary atresia following Kasai portoenterostomy using early perioperative biochemical data up to 3 months postoperatively.

Chuanping Xie … Jinshi Huang

Pediatric surgery international · 2026

Background

Biliary atresia (biliary atresia), a rare but life-threatening neonatal cholestatic disorder, necessitates Kasai portoenterostomy (kasai portoenterostomy) as the primary surgical intervention.

Methods

The study subjects were biliary atresia patients treated by a senior kasai portoenterostomy surgeon at our center (93 cases) and another senior kasai portoenterostomy surgeon at Jiangxi Children's Hospital (61 cases) from January 2017 to December 2022.

n = 154 patients

Results

how well the model separated infants whose own liver survived 2 years from those who needed a transplant; higher means b

AUC 0.86 (95% CI 0.74 to 0.95)

null 0

0.74

0.95

CI excludes the null - significant

More results

The five traditional machine learning models showed varying performance, with RF demonstrating the highest average AUC in the training set (AUC = 0.795, 95% CI 0.709-0.881).

GGT_3M, ALB_3M, DBIL_3M, DBIL_1M and GLO_1W were identified as the most critical predictive features.

More results

A transfer learning-based clinical decision support system was deployed, providing dynamic visualization of individualized 24-month native liver survival trajectories.

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Conclusion · 1 of 2

Early perioperative biochemical data-driven machine learning models, enhanced by transfer learning, enable accurate prediction of 2-year native liver survival in biliary atresia.

Conclusion · 2 of 2

GGT_3M, ALB_3M, DBIL_3M, DBIL_1M, and GLO_1W are among the most influential predictors for 2-year native liver survival after kasai portoenterostomy procedure.

Post

Transfer learning prediction of 2-year native liver survival in biliary atresia following Kasai portoenterostomy using early perioperative biochemical data up to 3 months postoperatively.

Transfer-learning model predicted 2-year native liver survival after Kasai portoenterostomy for biliary atresia

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