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New research · Obstetrics & Gynecology
Medical sciences (Basel, Switzerland) · 1w
Cohort studyMedical sciences (Basel, Switzerland) · 2026

Improved Prognostic Staging in Endometrial Cancer: Clinical Impact of Aggressive Subtypes in a Multicenter Cohort.

Tatiana Cuesta-Guardiola, Alicia Quirós, Pluvio Jesús Coronado Martín, Augusto Pereira Sánchez
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Obstetrics & GynecologyCohort study

Aggressive endometrial cancer subtypes were linked to markedly shorter overall survival

Improved Prognostic Staging in Endometrial Cancer: Clinical Impact of Aggressive Subtypes in a Multicenter Cohort.

Tatiana Cuesta-Guardiola … Augusto Pereira Sánchez
Medical sciences (Basel, Switzerland) · 2026
Purpose

Assessment of the impact on survival of endometrial carcinoma according to the 2009 FIGO (International Federation of Gynecology and Obstetrics) classification and the new FIGO 2023 classification highlighting the worse prognosis of the aggressive subtypes.

Methods

This multicenter retrospective study included 1181 patients with endometrial cancer.

n = 1181 patients
Results

people with aggressive tumor types typically lived a much shorter time overall

Aggressive
35.7months
Non-aggressive
60months
More results

A novel classification based on FIGO 2023 was developed, integrating histological aggressiveness into a different stage and combining early non-aggressive stages in only one stage.

While FIGO 2009 and 2023 classifications showed prognostic value, the new model improved risk stratification, clearly distinguishing high-risk groups.

More results

Multivariate analysis identified aggressive subtype, stage, age, diabetes, myometrial invasion and lymphovascular invasion as independent predictors.

“
Conclusion · 1 of 2

Aggressive histological subtype in endometrial cancer should carry greater prognostic weight in terms of survival and clinical management.

Conclusion · 2 of 2

Our findings support a potential shift in the current paradigm for these relatively rare but high-risk cases.

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