Low-grade serous ovarian cancer in Indonesia: Insights from the largest multicenter cohort in a…

Cohort studyMolecular and clinical oncology· Aug 2026

Low-grade serous ovarian cancer in Indonesia: Insights from the largest multicenter cohort in a middle-income country.

Brahmana Askandar Tjokroprawiro, Khoirunnisa Novitasari, Wita Saraswati … Eccita Rahestyningtyas

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Gynecologic CancerCohort studyPrognosisQ3IF 1.9

Residual disease after surgery was the strongest independent predictor of death in low-grade serous ovarian cancer

Low-grade serous ovarian cancer in Indonesia: Insights from the largest multicenter cohort in a middle-income country.

Brahmana Askandar Tjokroprawiro … Eccita Rahestyningtyas

Molecular and clinical oncology · Aug 2026

Background

Low-grade serous ovarian cancer (low-grade serous ovarian cancer), a rare subtype of epithelial ovarian cancer, is characterized by indolent growth and limited chemosensitivity.

Purpose

The present study aimed to describe the clinical and pathological characteristics of patients with low-grade serous ovarian cancer in Indonesia.

Methods

Of the cohort, ~50% presented with advanced-stage disease (International Federation of Gynecology and Obstetrics III-IV, 50%).

n = 160 patients

5.59

Results

5.59

Leftover tumour after surgery was linked to a 5.59-fold higher death rate (adjusted HR)

n = 160 patients

More results

Ascites and elevated cancer antigen-125 levels were observed in 43.1 and 70.6% of patients, respectively.

The overall recurrence rate was 10, and 92.5% of patients were alive at the last follow-up.

Kaplan-Meier analysis showed worse survival in patients with advanced-stage disease and residual disease.

More results

In univariate Cox regression, residual disease (HR, 7.93) and recurrence (HR, 10.06) showed the strongest associations with mortality.

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Conclusion

In this multicenter cohort, residual disease was the key determinant of survival, underscoring the importance of complete cytoreductive surgery and early diagnosis.

Low-grade serous ovarian cancer in Indonesia: Insights from the largest multicenter cohort in a middle-income country.

Low-grade serous ovarian cancer in Indonesia: Insights from the largest multicenter cohort in a middle-income country.

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