Persistent kidney dysfunction after leptospirosis-associated acute kidney injury: a case series from coastal…

Cohort studyInternational urology and nephrology· Jul 2026

Persistent kidney dysfunction after leptospirosis-associated acute kidney injury: a case series from coastal Karnataka, India.

Astha Sethi, Attur Ravindra Prabhu, V Shashidhar, Nitin Gupta

NephrologyCohort studyClinical practiceQ2IF 2.2

14% of leptospirosis acute kidney injury survivors had chronic kidney disease at three months

Persistent kidney dysfunction after leptospirosis-associated acute kidney injury: a case series from coastal Karnataka, India.

Astha Sethi … Nitin Gupta

International urology and nephrology · Jul 2026

Background

Leptospirosis has been infrequently associated with persistent kidney dysfunction fulfilling the criteria for chronic kidney disease (chronic kidney disease).

Purpose

This study aimed to describe the clinical profile, laboratory findings, treatment requirements, and kidney outcomes of patients without recognised chronic kidney disease risk factors who had persistent kidney dysfunction fulfilling chronic kidney disease criteria at three-month follow-up after leptospirosis-associated Acute Kidney Injury (Acute Kidney Injury).

Methods

With leptospirosis-associated Acute Kidney Injury who fulfilled Kidney Disease: Improving Global Outcomes (KDIGO) criteria for chronic kidney disease at three-month follow-up were included.

n = 101 hospitalised patients

14.0%

Results

14.0%

About 1 in 7 survivors without prior risk factors had persistent kidney damage

n = 101 hospitalised patients

More results

Among 101 hospitalised patients with leptospirosis, 67 (66.3%) developed Acute Kidney Injury.

Of these, 7 (10.4%) died in hospital, and 17 (28.3%) of the 60 survivors did not undergo serum creatinine testing at three-month follow-up.

More results

Jaundice was present in 4/6, 66.7%, of patients, leukocytosis was observed in all patients, and thrombocytopenia was present in all patients.

Myocarditis was noted in 2/6, 33.3%, of patients.

“

Conclusion · 1 of 2

Severe leptospirosis-associated Acute Kidney Injury may be followed by persistent kidney dysfunction at three months despite improvement in serum creatinine from peak values.

Conclusion · 2 of 2

Persistent creatinine elevation at discharge may be an important clinical warning sign.

Persistent kidney dysfunction after leptospirosis-associated acute kidney injury: a case series from coastal Karnataka, India.

Persistent kidney dysfunction after leptospirosis-associated acute kidney injury: a case series from coastal Karnataka, India.

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