Post

New research · Pulmonology & Critical Care
Microbiology spectrum · 17h
Cohort studyMicrobiology spectrum · 2026

Difficult-to-treat resistant Gram-negative bacteria and genomic resemblances between colonization and infection among patients in an intensive care unit of a tertiary care hospital in Bangladesh.

Gazi Md Salahuddin Mamun, Md Shahinur Rahaman, Sanzida Khan … Fahmida Chowdhury
Read paper
Pulmonology & Critical CareCohort study

ICU colonization with difficult-to-treat-resistant Gram-negative bacteria linked to more subsequent infections

Difficult-to-treat resistant Gram-negative bacteria and genomic resemblances between colonization and infection among patients in an intensive care unit of a tertiary care hospital in Bangladesh.

Gazi Md Salahuddin Mamun et al. · Microbiology spectrum · 2026
Background

Colonization with difficult-to-treat-resistant Gram-negative bacteria (DTR-GNB) increases the risk of subsequent infections with limited treatment options.

Purpose

This study aimed to assess the burden of DTR-GNB colonization in ICU patients, explore its association with clinical outcomes, and examine genomic similarities.

Methods

This secondary analysis included patients enrolled within 24 h of ICU admission between July 2023 and January 2024.

n = 373 patients
Results

Colonized patients had about 2-fold higher risk of later infection than non-colonized

RR 1.57 (95% CI 1.34 to 1.84)
null = 11.341.84
CI excludes the null - significant
More results

Among 373 patients, 181 (48.5%) were colonized with DTR-GNB; 76 (20.4%) at enrollment, and 105 (53.0%) acquired during hospital stay.

DTR-GNB-infected patients had a higher risk of death (RR: 1.57, 95% CI: 1.34-1.84) compared to patients without DTR-GNB infection.

More results

WGS revealed that 13 of 14 paired colonization-infection isolates were conspecific, with three pairs being highly clonal; whereas the remaining pairs showed greater genomic divergence, consistent with the SNP and phylogenetic analyses.

Alarmingly, more than 90% of patients infected with DTR-GNB expired in the hospital.

“
Conclusion

Addressing this emerging resistance phenotype is critical to improving patient safety and reducing the burden on healthcare systems.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cohort Study
0.92
AUC 0.92: strong discrimination between good and poor recovery outcomes
Cohort Study
OR: 2.172
sepsis-related clotting issues are associated with over twice the odds of hospital death
Cohort Study
1.55
patients with active inflammatory bowel disease had higher odds of respiratory syncytial virus infection
Cohort Study
75.3%
definitive diagnosis reached in most peripheral lung growths sampled by this freeze-biopsy method
Cohort Study
84 vs. 39 days
carbapenem-resistant infection meant far longer hospital stays than the drug-susceptible group
Guideline
at least 24 hours
the minimum time to maintain desired body temperature for unconscious patients
Guideline
116mg/dL
lower alpha-1 antitrypsin protein levels than this trigger a two-step diagnosis
Cohort Study
odds ratio = 0.273
morphine was associated with a lower risk of delirium compared to fentanyl