Difficult-to-treat resistant Gram-negative bacteria and genomic resemblances between colonization and…

Cohort studyMicrobiology spectrum· Jul 2026

Difficult-to-treat resistant Gram-negative bacteria and genomic resemblances between colonization and infection among patients in an intensive care unit of a tertiary care hospital in Bangladesh.

Gazi Md Salahuddin Mamun, Md Shahinur Rahaman, Sanzida Khan … Fahmida Chowdhury

Pulmonology & Critical CareCohort studyQ1IF 4.0

ICU colonization with difficult-to-treat-resistant Gram-negative bacteria linked to more subsequent infections

Difficult-to-treat resistant Gram-negative bacteria and genomic resemblances between colonization and infection among patients in an intensive care unit of a tertiary care hospital in Bangladesh.

Gazi Md Salahuddin Mamun … Fahmida Chowdhury

Microbiology spectrum · Jul 2026

Background

Colonization with difficult-to-treat-resistant Gram-negative bacteria (difficult-to-treat-resistant Gram-negative bacteria) increases the risk of subsequent infections with limited treatment options.

Purpose

This study aimed to assess the burden of difficult-to-treat-resistant Gram-negative bacteria colonization in ICU patients, explore its association with clinical outcomes, and examine genomic similarities.

Methods

This secondary analysis included patients enrolled within 24 h of ICU admission between July 2023 and January 2024.

n = 373 patients

Results

Colonized patients had about 2-fold higher risk of later infection than non-colonized

RR 1.57 (95% CI 1.34 to 1.84)

CI excludes the null - significant

More results

Among 373 patients, 181 (48.5%) were colonized with difficult-to-treat-resistant Gram-negative bacteria; 76 (20.4%) at enrollment, and 105 (53.0%) acquired during hospital stay.

More results

Difficult-to-treat-resistant Gram-negative bacteria-infected patients had a higher risk of death (RR: 1.57, 95% CI: 1.34-1.84) compared to patients without difficult-to-treat-resistant Gram-negative bacteria infection.

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Conclusion

Addressing this emerging resistance phenotype is critical to improving patient safety and reducing the burden on healthcare systems.

Difficult-to-treat resistant Gram-negative bacteria and genomic resemblances between colonization and infection among patients in an intensive care unit of a tertiary care hospital in Bangladesh.

Difficult-to-treat resistant Gram-negative bacteria and genomic resemblances between colonization and infection among patients in an intensive care unit of a tertiary care hospital in Bangladesh.

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