Congenital Cytomegalovirus Among Newborns in Neonatal Intensive Care Units, United States, 2010-2020.

Cohort studyBirth defects research· Jul 2026

Congenital Cytomegalovirus Among Newborns in Neonatal Intensive Care Units, United States, 2010-2020.

Kelley Raines, Ashrita Rau, Reese Clark … Tatiana M Lanzieri

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Pulmonology & Critical CareCohort studyDiagnosisQ2IF 1.9

Among tested neonatal intensive care newborns, 5.6% had congenital cytomegalovirus infection.

Congenital Cytomegalovirus Among Newborns in Neonatal Intensive Care Units, United States, 2010-2020.

Kelley Raines … Tatiana M Lanzieri

Birth defects research · Jul 2026

Background

Little is known about routine testing practices and diagnosis of congenital cytomegalovirus (cCMV) infection in newborns admitted to neonatal intensive care units (neonatal intensive care units) across the United States.

Methods

We analyzed Pediatrix Clinical Data Warehouse data, comprising 840,988 newborns admitted to 389 neonatal intensive care units in 35 states during 2010-2020.

Results

Of newborns tested, 5.6% had confirmed congenital cytomegalovirus, a viral infection present at birth.

More results

During 2010-2020, among those tested, the proportion with ≤ 1 clinical sign increased from 12.9% to 32.0%.

Hepatosplenomegaly, petechiae, microcephaly, hepatitis, thrombocytopenia, chorioretinitis, and intracranial calcifications were associated with increased odds of both cCMV testing and diagnosis, with varying specificity.

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Conclusion

Despite low CMV testing rates in the neonatal intensive care units, a shift toward testing newborns with fewer clinical signs occurred over time.

Congenital Cytomegalovirus Among Newborns in Neonatal Intensive Care Units, United States, 2010-2020.

Congenital Cytomegalovirus Among Newborns in Neonatal Intensive Care Units, United States, 2010-2020.

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