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New research · Pulmonology & Critical Care
Birth defects research · 17h
Cohort studyBirth defects research · 2026

Congenital Cytomegalovirus Among Newborns in Neonatal Intensive Care Units, United States, 2010-2020.

Kelley Raines, Ashrita Rau, Reese Clark … Tatiana M Lanzieri
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Pulmonology & Critical CareCohort study

Among tested neonatal intensive care newborns, 5.6% had congenital cytomegalovirus infection.

Congenital Cytomegalovirus Among Newborns in Neonatal Intensive Care Units, United States, 2010-2020.

Kelley Raines et al. · Birth defects research · 2026
Background

Little is known about routine testing practices and diagnosis of congenital cytomegalovirus (cCMV) infection in newborns admitted to neonatal intensive care units (NICUs) across the United States.

Methods

We analyzed Pediatrix Clinical Data Warehouse data, comprising 840,988 newborns admitted to 389 NICUs in 35 states during 2010-2020.

Results

Of newborns tested, 5.6% had confirmed congenital cytomegalovirus, a viral infection present at birth.

12.9%
Before
32%
After
More results

During 2010-2020, among those tested, the proportion with ≤ 1 clinical sign increased from 12.9% to 32.0%.

Hepatosplenomegaly, petechiae, microcephaly, hepatitis, thrombocytopenia, chorioretinitis, and intracranial calcifications were associated with increased odds of both cCMV testing and diagnosis, with varying specificity.

“
Conclusion

Despite low CMV testing rates in the NICU, a shift toward testing newborns with fewer clinical signs occurred over time.

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