Differential methylation of immune-related genes and its clinical significance in systemic lupus erythematosus: insights from TET2, FOXP3, and IFI44L genes.

However, methylation levels of FOXP3 and TET2 did not show significant differences between the two groups.

Besides, higher FOXP3 methylation was observed in early-onset systemic lupus erythematosus patients and those with renal involvement, characterized by positive correlations with CRP and anti-dsDNA antibodies, and negative correlations with complement C3 and C4 levels.