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New research · Gastroenterology
British journal of cancer · 23h
Cohort studyBritish journal of cancer · 2026

Routine duodenal papillary biopsy enhances detection of duodenal papillary adenoma in familial adenomatous polyposis patients: a prospective cohort study.

Wei-Na Jing, Bin-Yang Luo, Fei-Fan Chen … Zhu Wang
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GastroenterologyCohort study

Routine duodenal papilla biopsy detected adenomas in 62.75% of familial adenomatous polyposis patients.

Routine duodenal papillary biopsy enhances detection of duodenal papillary adenoma in familial adenomatous polyposis patients: a prospective cohort study.

Wei-Na Jing et al. · British journal of cancer · 2026
Background

Familial adenomatous polyposis (FAP) confers high periampullary malignancy risk.

Purpose

This prospective cohort study evaluated whether protocolized routine biopsy improves adenoma detection regardless of endoscopic appearance.

Methods

Fifty-one FAP patients underwent esophagogastroduodenoscopy with protocolized routine duodenal papilla biopsies, independent of macroscopic findings.

62.75%
Results
routine biopsy detected precancerous growths in the intestinal bump for familial adenomatous polyposis patients
More results

Crucially, 53.13% (17/32) occurred in endoscopically normal papillae, while 84.38% (27/32) of adenoma patients had prior negative endoscopic screenings.

More results

Beyond Spigelman stage, significant correlations with papilla adenomas included combined gastric antral adenomas (R = 0.470, p = 0.037), use of transparent cap (R = 0.691, p = 0.003), and abnormal papillary appearance (R = 0.885, p < 0.001).

“
Conclusion · 1 of 2

Routine papilla biopsy significantly improves adenoma detection in FAP patients, especially with transparent caps.

Conclusion · 2 of 2

Gastric antral adenomas serve as potential predictors of ampullary neoplasia, supporting their integration into risk-adapted surveillance strategies.

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