ANGPTL4 in gestational diabetes: a diagnostic biomarker linked to placental senescence.

The classification model integrating ANGPTL4 and DST demonstrated favorable retrospective discriminatory performance (training set AUC = 0.95; validation set AUC = 0.87).

Cell communication analysis predicted potential ligand-receptor interactions between ANGPTL4 and ITGA5/ITGB1/SDC4 in extravillous trophoblasts.

Differentially expressed senescence-related genes in Gestational Diabetes Mellitus placentas were highly enriched in lipid metabolism pathways, aligning with ANGPTL4's known function.

These correlative findings generate testable hypotheses linking ANGPTL4‑mediated signaling to placental senescence.