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New research · Endocrinology
Cardiovascular diabetology. Endocrinology reports · 23h
ReviewCardiovascular diabetology. Endocrinology reports · 2026

Concomitant use of SGLT2 inhibitors and GLP-1 receptor agonists in patients with heart failure.

Reza Khademi, Saeed Shoar
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EndocrinologyReview

SGLT2 inhibitors reduce heart failure hospitalization and cardiovascular death rates.

Concomitant use of SGLT2 inhibitors and GLP-1 receptor agonists in patients with heart failure.

Reza Khademi et al. · Cardiovascular diabetology. Endocrinology reports · 2026
Background

Heart failure (HF) is a major cardiovascular complication of type 2 diabetes mellitus (T2DM).

Methods

Emerging data from meta-analyses, subgroup analyses, and observational studies suggest possible additive benefits of combination therapy; however, most evidence is indirect and not derived from dedicated randomized heart failure trials.

Results
SGLT2 inhibitors lower the chance of heart failure hospital stays and heart-related deaths
More results

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) both improve cardiovascular outcomes, but their comparative roles in HF and the potential value of combination therapy remain uncertain.

More results

In contrast, GLP-1 receptor agonists have a more modest effect on HF hospitalization (approximately 11% risk reduction; HR 0.89) while primarily reducing atherosclerotic cardiovascular events and supporting weight and metabolic control.

“
Conclusion · 1 of 2

SGLT2 inhibitors are established therapies for reducing HF outcomes, whereas GLP-1 receptor agonists primarily address cardiometabolic risk with uncertain direct HF benefit.

Conclusion · 2 of 2

Combination therapy is mechanistically plausible but remains insufficiently supported by dedicated randomized evidence in HF populations. Further prospective trials are required to define its clinical role.

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