Management of Adult Bronchiectasis: An American College of Chest Physicians Clinical Practice Guideline.

All recommendations are conditional, primarily based on low-certainty evidence. Bronchiectasis research should aim to address many of the uncertainties in management, and priorities are identified within each PICO question.

Accurate phenotyping and endotyping may help guide therapeutic decision-making and risk stratification. Treatment interventions must consider potential treatment burdens, including cost, and impact on quality of life.

Finally, shared decision-making with patients utilizing a multidisciplinary approach is paramount.