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New research · Hematology
Fish & shellfish immunology · 23h
Randomized trialFish & shellfish immunology · 2026

Hematology-centered characterization of β-glucan-mediated disease trajectory modulation during rock bream iridovirus (RBIV) infection.

Su-Mi Shin, Da-Seul Lee, Seok-Ju Lee … Myung-Hwa Jung
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HematologyRandomized trial

Beta-glucan treatment reduced rock bream iridovirus mortality to 60% in experimental infection.

Hematology-centered characterization of β-glucan-mediated disease trajectory modulation during rock bream iridovirus (RBIV) infection.

Su-Mi Shin et al. · Fish & shellfish immunology · 2026
Background

Rock bream iridovirus (RBIV) causes a rapid systemic infection, severe hematological disruption, and high mortality in rock bream (Oplegnathus fasciatus).

60%
Results
Cumulative mortality was 60% with beta-glucan, reduced from 100% in untreated fish.
More results

Although β-glucan is widely used as an immunostimulant in aquaculture, its influence on RBIV disease progression remains poorly understood.

Therefore, this study evaluated the effects of different β-glucan administration schedules on survival, viral dissemination, and blood-associated physiological responses during experimental RBIV infection.

More results

Compared with virus-only fish, β-glucan treatment improved survival while delaying systemic viral dissemination, reducing viral burden, and attenuating hematological deterioration throughout infection.

In contrast, biochemical responses showed comparatively limited treatment-associated effects.

“
Conclusion

These results further support the concept that preservation of hematological integrity represents a key component of disease resilience during RBIV infection.

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