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Cohort studyJournal of nuclear medicine technology · 2026

Simplified 18 F-FDG PET Myocardial Viability Preparation Protocol Reduces Hypoglycemia and Improves Workflow Efficiency While Maintaining Image Quality.

Amanda E Roby, Lindsey Harmon, Kelly Sander … K Lance Gould

CardiologyCohort study

Simplified PET protocol lowers hypoglycemia incidence to 3%.

Simplified 18 F-FDG PET Myocardial Viability Preparation Protocol Reduces Hypoglycemia and Improves Workflow Efficiency While Maintaining Image Quality.

Amanda E Roby et al. · Journal of nuclear medicine technology · 2026

Methods

18 F-FDG myocardial viability studies performed between 2007 and 2025 were retrospectively analyzed.

n = 955 studies

Results

lower incidence of low blood sugar with the simplified protocol

More results

Total imaging time decreased from 175 ± 41 min to 144 ± 25 min ( P < 0.001), representing a mean reduction of 31 min.

The number of BG measurements decreased from 8 ± 2 to 4 ± 1 ( P < 0.001).

Persistent blood-pool activity beyond 90 min decreased from 11% to 6% ( P = 0.2).

More results

Across the full cohort of 955 studies, the simplified protocol improved the proportion of good-or-better image quality from 81% to 87% ( P = 0.03) and reduced the rate of poor or nondiagnostic studies from 5.4% to 1% ( P < 0.001).

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Conclusion · 1 of 2

This simplified 18 F-FDG PET viability preparation protocol reduced hypoglycemia, shortened preparation and imaging times, decreased glucose monitoring requirements, and maintained or improved image quality.

Conclusion · 2 of 2

The protocol provides a safer, more efficient approach for myocardial viability imaging.

Post

Simplified 18 F-FDG PET Myocardial Viability Preparation Protocol Reduces Hypoglycemia and Improves Workflow Efficiency While Maintaining Image Quality.

Simplified PET protocol lowers hypoglycemia incidence to 3%.

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