Post

New research · Nephrology
Journal of the American Society of Nephrology : JASN · 23h
Cohort studyJournal of the American Society of Nephrology : JASN · 2026

Cardiovascular Risk Across Different Glomerular Diseases.

Luhua Jin, Jiao Liu, Caoxiang She … Sheng Nie
Read paper
NephrologyCohort study

Lupus nephritis is associated with a higher cardiovascular death risk.

Cardiovascular Risk Across Different Glomerular Diseases.

Luhua Jin et al. · Journal of the American Society of Nephrology : JASN · 2026
Background

It was well-established that patients with glomerulonephritis face an elevated cardiovascular risk, yet little was known about the differential impacts of various etiologies of glomerular disease on cardiovascular outcomes.

Purpose

In this large cohort study encompassing patients with distinct forms of glomerular nephritis, we aimed to compare the effects of different etiologies on cardiovascular death events.

Methods

Utilizing data from the China Renal Data System (CRDS) database, we identified 66,247 patients with glomerulonephritis across 14 distinct etiologies between 2000 and 2022.

Results
lupus nephritis patients have a cardiovascular death risk this many times higher than the general population
More results

Within a cohort of 66,247 patients with glomerulonephritis, immunoglobulin A (IgA) nephropathy (39%) was the most prevalent etiology, followed by lupus nephritis (17%) and membranous nephropathy (16%).

The overall crude cardiovascular death rates across glomerulonephritis subtypes ranged from 0.7 to 22.6 per 1,000 person-years.

More results

Furthermore, when compared directly to patients with minimal change disease, all other glomerulonephritis subtypes were associated with significantly greater cardiovascular death risk.

“
Conclusion

Patients with different underlying glomerular diseases exhibited markedly heterogeneous and elevated cardiovascular risk profiles.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Meta-analysis
13.82 h
citrate anticoagulation kept the blood-filter working longer before it clogged and had to be replaced
Cohort Study
HR 4.00
Severe kidney scarring linked to about 4-fold higher rate of graft failure
Cohort Study
14.0%
About 1 in 7 survivors without prior risk factors had persistent kidney damage
Animal / Preclinical
79 d
The toxic signal from cisplatin in the kidney takes 79 days to halve.
Cohort Study
3:54 vs. 4:41 h
recipients had shorter surgery time with the simultaneous robotic approach
Guideline
approximately 80%
how many people with early AL amyloidosis are expected to live for 5 years
Cohort Study
HR 2.144
Higher inflammatory index means more than double the risk of abdominal lining inflammation
Cohort Study
≥9
a higher amount of damage in the kidney tissue before transplant