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New research · Nephrology
Archives of endocrinology and metabolism · 1d
Cohort studyArchives of endocrinology and metabolism · 2026

GLP-1 receptor agonists in kidney transplant recipients with post-transplant diabetes: efficacy and safety outcomes from a retrospective cohort study.

Ricardo E T Navarrete, Joana C Freitas, Isabel Fonseca … Joao Roberto Sa
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NephrologyCohort study

GLP-1 receptor agonists are associated with lower total cholesterol in kidney transplant recipients.

GLP-1 receptor agonists in kidney transplant recipients with post-transplant diabetes: efficacy and safety outcomes from a retrospective cohort study.

Ricardo E T Navarrete et al. · Archives of endocrinology and metabolism · 2026
Purpose

To assess the efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in kidney transplant recipients (KTRs) with post-transplant diabetes mellitus (PTDM).

Methods

This retrospective, single-center cohort study included 24 KTRs with PTDM who initiated GLP-1 RA therapy as an add-on to existing treatments between August 2013 and April 2024.

n = 5
-41.5
Results
mg/dL
GLP-1 RAs were associated with lower total cholesterol
n = 5
More results

HbA1c decreased by -0.2% (p = 0.362), while FPG increased by +12.1 mg/dL (p = 0.232).

Serum creatinine and estimated glomerular filtration rate remained stable (-0.09 mg/dL, p = 0.305; +3.2 mL/min/1.73 m2, p = 0.206, respectively).

Nausea occurred in 21% (n = 5), and no other severe adverse events were reported.

“
Conclusion · 1 of 2

In KTRs with PTDM, GLP-1 RA therapy was associated with improvements in lipid profile and blood pressure, accompanied by non-significant trends toward weight reduction and stable renal function, and demonstrated an acceptable safety profile.

Conclusion · 2 of 2

Prospective studies are warranted to confirm long-term cardiorenal benefits.

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