Post

New research · Nephrology
American journal of nephrology · 1d
Cohort studyAmerican journal of nephrology · 2026

Outcomes of Dual Kidney Transplantation from Donors with High Pre-implantation Biopsy Scores.

Giorgia Comai, Michele Provenzano, Elisa Gessaroli … Valeria Corradetti
Read paper
NephrologyCohort study

Dual kidney transplantation can use grafts with Karpinski scores of 9 or higher.

Outcomes of Dual Kidney Transplantation from Donors with High Pre-implantation Biopsy Scores.

Giorgia Comai et al. · American journal of nephrology · 2026
Background

The persistent shortage of transplantable kidneys has increased reliance on marginal organs, yet kidneys with advanced chronic lesions on pre-implantation biopsy are frequently discarded.

Methods

We conducted a retrospective cohort study of 262 adult deceased-donor kidney transplant recipients undergoing pre-implantation biopsy at a single Italian center between 2014 and 2021.

n = 262 adult
Results

a higher amount of damage in the kidney tissue before transplant

SKT <9
142
DKT <9
35
DKT ≥9
85
More results

DKT donors were older and had higher KDPI/KDRI than SKT donors.

Kaplan-Meier analyses showed no significant differences in overall graft failure, all-cause mortality, or death-censored graft failure.

In multivariable Cox regression, allocation group was not independently associated with overall graft failure.

“
Conclusion · 1 of 2

In this real-world allocation cohort, kidneys with combined Karpinski score ≥9 achieved outcomes comparable to lower-score grafts when allocated as DKT.

Conclusion · 2 of 2

These findings support the use of DKT as a strategy to safely expand the donor pool and suggest that high histological chronicity should not automatically preclude transplantation when integrated with clinical and functional donor assessment.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cohort Study
hazard ratio 4.00
high genetic risk and severe CKM syndrome meant a much higher risk of knee arthritis
Cohort Study
11.1%
hospitalizations for heart inflammation in dialysis patients that included severe heart issues
Cohort Study
HR 4.00
Severe kidney scarring linked to about 4-fold higher rate of graft failure
Guideline
almost 30%
people with Von-Hippel Lindau syndrome are affected by kidney cancer
Cohort Study
14.0%
About 1 in 7 survivors without prior risk factors had persistent kidney damage
Guideline
“This consensus aims to clarify for which patients renal denervation may be a viable therapeutic option, identify the main clinical and procedural considerations for its implementation, and promote its optimal and safe use through appropriate patient selection and multidisciplinary evaluation.”
Cohort Study
-41.5 mg/dL
GLP-1 RAs were associated with lower total cholesterol
Guideline
approximately 80%
how many people with early AL amyloidosis are expected to live for 5 years