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New research · Nephrology
PloS one · 1d
Cohort studyPloS one · 2026

Predictive value of complete blood cell count-based inflammatory markers for peritonitis risk in peritoneal dialysis patients: A multicenter cohort study.

Xue Li, Wenlong Qiu, Qingdong Xu … Na Tian
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NephrologyCohort study

Elevated systemic immune-inflammatory index is associated with higher peritonitis risk.

Predictive value of complete blood cell count-based inflammatory markers for peritonitis risk in peritoneal dialysis patients: A multicenter cohort study.

Xue Li et al. · PloS one · 2026
Background

Peritonitis is a serious complication of peritoneal dialysis (PD).

Purpose

This multicenter cohort study aimed to evaluate and compare these indices to identify the best predictor of PDAP.

Methods

We retrospectively enrolled 2,036 PD patients from 10 centers.

n = 147 patients
Results
Higher inflammatory index means more than double the risk of abdominal lining inflammation
n = 147 patients
More results

The median age was 51.0 years, 55.01% were male, and median dialysis vintage was 49.47 months.

Diabetes prevalence was 21.02%.

Over the follow-up, 147 patients (7.22%) developed peritonitis.

Among the indices evaluated, PIV, SII, and PLR showed significant nonlinear associations with peritonitis risk (all P < 0.05).

“
Conclusion · 1 of 2

Elevated PIV, SII, and PLR levels at PD initiation independently predict higher peritonitis risk.

Conclusion · 2 of 2

Although their discriminative ability is moderate, these routine, cost-effective indices may aid risk stratification and help identify patients needing closer monitoring or preventive interventions.

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