Association between triglyceride to high-density lipoprotein cholesterol ratio and new-onset diabetes…

Cohort studyArchives of endocrinology and metabolism· Jul 2026

Association between triglyceride to high-density lipoprotein cholesterol ratio and new-onset diabetes mellitus.

Chunhui Yin, Qi Qi, Xinyu Wu … Kangbo Li

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EndocrinologyCohort studyPrognosisQ3IF 1.7

Higher triglyceride to high-density lipoprotein cholesterol ratio is associated with increased new-onset diabetes mellitus.

Association between triglyceride to high-density lipoprotein cholesterol ratio and new-onset diabetes mellitus.

Chunhui Yin … Kangbo Li

Archives of endocrinology and metabolism · Jul 2026

Purpose

To examine the association between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and the onset of diabetes mellitus (diabetes mellitus) within an ongoing prospective cohort in China.

Methods

Were categorized into four groups according to their TG/HDL-C ratio quartiles.

n = 38,210 individuals

Results

a higher triglyceride to HDL cholesterol ratio means a higher risk of new diabetes

HR 1.09 (95% CI 1.06 to 1.13)

CI excludes the null - significant

More results

Kaplan-Meier curves revealed that the cumulative diabetes mellitus incidence across quartiles 1 to 4 was 40.95%, 42.04%, 41.42%, and 44.38%, respectively.

The risk of developing diabetes mellitus increased over time according to the baseline TG/HDL-C ratio quartiles.

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Conclusion

TG/HDL-C ratio is significantly and positively associated with new-onset diabetes mellitus.

Association between triglyceride to high-density lipoprotein cholesterol ratio and new-onset diabetes mellitus.

Association between triglyceride to high-density lipoprotein cholesterol ratio and new-onset diabetes mellitus.

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