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Cohort studyArchives of endocrinology and metabolism · 2026

Association between triglyceride to high-density lipoprotein cholesterol ratio and new-onset diabetes mellitus.

Chunhui Yin, Qi Qi, Xinyu Wu … Kangbo Li

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EndocrinologyCohort study

Higher triglyceride to high-density lipoprotein cholesterol ratio is associated with increased new-onset diabetes mellitus.

Association between triglyceride to high-density lipoprotein cholesterol ratio and new-onset diabetes mellitus.

Chunhui Yin et al. · Archives of endocrinology and metabolism · 2026

Purpose

To examine the association between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and the onset of diabetes mellitus (DM) within an ongoing prospective cohort in China.

Methods

Were categorized into four groups according to their TG/HDL-C ratio quartiles.

n = 38,210 individuals

Results

a higher triglyceride to HDL cholesterol ratio means a higher risk of new diabetes

HR 1.09 (95% CI 1.06 to 1.13)

CI excludes the null - significant

More results

Kaplan-Meier curves revealed that the cumulative DM incidence across quartiles 1 to 4 was 40.95%, 42.04%, 41.42%, and 44.38%, respectively.

The risk of developing DM increased over time according to the baseline TG/HDL-C ratio quartiles.

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Conclusion

TG/HDL-C ratio is significantly and positively associated with new-onset DM.

Post

Association between triglyceride to high-density lipoprotein cholesterol ratio and new-onset diabetes mellitus.

Higher triglyceride to high-density lipoprotein cholesterol ratio is associated with increased new-onset diabetes mellitus.

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