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New research · Pediatrics
Journal of computer assisted tomography · 23h
Cross-sectionalJournal of computer assisted tomography · 2026

Complementary Role of Whole-Body MRI and CT in Hematologic Malignancies and Bone Marrow Disorders.

Elena Ghotbi, Matthew Frick, Joselle Cook, Francis Baffour
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PediatricsCross-sectional

Whole-body CT and MRI show high agreement in detecting multiple myeloma.

Complementary Role of Whole-Body MRI and CT in Hematologic Malignancies and Bone Marrow Disorders.

Elena Ghotbi et al. · Journal of computer assisted tomography · 2026
Methods

Whole-body cross-sectional imaging has largely replaced skeletal survey as the standard for evaluating hematologic malignancies and bone marrow disorders, but the practical choice between whole-body low-dose CT (WBCT) and whole-body MRI (WBMRI) remains incompletely resolved.

n = 152 patients
Results

This shows very high agreement between CT and MRI scans for detecting multiple myeloma

concordance 0.80 (95% CI 0.67 to 0.89)
null = 00.670.89
CI excludes the null - significant
More results

This clinical review provides a practical, scenario-based comparison of WBCT and WBMRI across diagnosis, staging, treatment response, and surveillance.

We emphasize real-world practical considerations, including scanner access, expertise, patient tolerance, radiation considerations, and cost.

More results

Across all included disease categories, the broader pooled concordance estimate was 0.797 (95% CI: 0.667-0.885) with substantial heterogeneity reflecting variability in clinical context, reference standard, and protocol.

WBMRI dominates in non-neoplastic marrow disorders where marrow characterization is essential.

“
Conclusion

Modality selection should be guided by the specific clinical scenario, available resources, and patient factors rather than by global judgments of modality superiority.

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