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New research · Radiology
Hepatology communications · 1d
Cohort studyHepatology communications · 2026

Incidence and diagnostic yield of repeat imaging-based screening for hepatic arteriovenous malformations in patients with HHT.

Benjamin Cho, Leena Usman, Torianna Lomax Truong … Jin Ge
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RadiologyCohort study

Repeat liver imaging in hereditary hemorrhagic telangiectasia patients detects 6.7% clinically significant malformations.

Incidence and diagnostic yield of repeat imaging-based screening for hepatic arteriovenous malformations in patients with HHT.

Benjamin Cho et al. · Hepatology communications · 2026
Background

Hepatic arteriovenous malformations (HAVMs) are a common visceral manifestation of hereditary hemorrhagic telangiectasia that can lead to heart failure and biliary ischemia.

Purpose

We sought to clarify the prevalence of clinically significant HAVMs following negative or nonactionable imaging.

6.7%
Results
Among hereditary hemorrhagic telangiectasia patients re-imaged, 6.7% had clinically significant liver arteriovenous malformations.
More results

We isolated all adult patients with hereditary hemorrhagic telangiectasia evaluated at the University of California, San Francisco HHT Center of Excellence between 2013 and 2025.

Of the 195, 30 (15.4%) underwent repeat hepatic imaging.

Across 48 total repeat imaging studies, the detection rate per study was 4.2%.

More results

Across 386.5 person-years of follow-up, the incidence rate of clinically significant HAVM recognition was 0.52 per 100 person-years.

“
Conclusion · 1 of 2

Both instances of HAVM identification reflected evolving clinical features and reinterpretation of prior imaging, not de novo lesion development.

Conclusion · 2 of 2

These findings support periodic reassessment of initial negative/nonactionable screening studies, with a low threshold for reassessment in the presence of new signs and symptoms.

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