Sonorheometry Quantra QPlus Characteristics in Adult Cardiac Surgical Patients: An Observational Cohort Study.
PCS accurately detects low platelet counts during cardiopulmonary bypass.
Sonorheometry Quantra QPlus Characteristics in Adult Cardiac Surgical Patients: An Observational Cohort Study.
Validation of the Quantra QPlus sonorheometry cartridge (Hemosonics Corporation) in cardiac surgical patients is limited.
We performed a retrospective observational study of 511 cardiac surgical patients at a single academic medical center during the first year of routine sonorheometry application during and after cardiac surgery (2024-2025).
A clot time heparinase value of 153 seconds discriminated elevated international normalized ratio (international normalized ratio) values post-cardiopulmonary bypass, with an area under the curve (AUC) from 0.78 to 0.84 depending on the international normalized ratio cutoff.
An FCS of 1.5 to 2.3 hPa discriminated hypofibrinogenemia post-cardiopulmonary bypass with an AUC from 0.88 to 0.97 depending on the fibrinogen cutoff.
A PCS of 6.9 to 12.2 hPa detected thrombocytopenia post-cardiopulmonary bypass with an AUC from 0.90 to 0.97, depending on the platelet cutoff.
Clot time heparinase, PCS, and FCS demonstrated high discriminative accuracy for abnormalities in corresponding laboratory assays.
cardiopulmonary bypass and hypofibrinogenemia modified the relationship between PCS and platelet count, with a higher platelet count observed for a given PCS during cardiopulmonary bypass and when fibrinogen was low.