Association of Hormone Therapy with Long-Term Outcomes After Chemoradiation for Locally Advanced Cervical…

Cohort studyAmerican journal of obstetrics and gynecology· Jul 2026

Association of Hormone Therapy with Long-Term Outcomes After Chemoradiation for Locally Advanced Cervical Cancer.

Ting-Fang Lu, Yu-Hsiang Shih, Yen-Fu Chen … Chien-Hsing Lu

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Gynecologic CancerCohort studyTreatmentQ1IF 4.8

Hormone therapy is associated with improved overall survival in young cervical cancer patients.

Association of Hormone Therapy with Long-Term Outcomes After Chemoradiation for Locally Advanced Cervical Cancer.

Ting-Fang Lu … Chien-Hsing Lu

American journal of obstetrics and gynecology · Jul 2026 · Q1 in Obstetrics & Gynecology

Background

Concurrent chemoradiotherapy for locally advanced cervical cancer frequently induces premature menopause in young patients, resulting in long-term metabolic, skeletal, and cardiovascular morbidity.

Purpose

To evaluate the association of hormone therapy with long-term metabolic, skeletal, cardiovascular, oncologic, and survival outcomes in young patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy.

Methods

Who died or developed primary outcomes before the 1-year landmark were excluded.

n = 4,656 patients

Results

HR, 0.81

hormone therapy was associated with a better chance of living longer

n = 4,656 patients

More results

Among patients initially classified as non-hormone therapy users, 112 of 2,328 (4.8%) subsequently had recorded hormone therapy exposure after the 1-year index event.

Cumulative hormone therapy duration and discontinuation during follow-up were not reliably quantifiable in the aggregate platform.

More results

There were no significant differences in incidences of thromboembolism, breast cancer, or colorectal cancer.

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Conclusion · 1 of 2

In this large multinational cohort of young patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy, initiating hormone therapy within the first year was associated with reduced metabolic, skeletal, and cerebrovascular morbidity and improved overall survival, without an increased risk of oncologic outcomes during long-term follow-up.

Conclusion · 2 of 2

These findings support the safety and potential systemic health benefits of hormone therapy in this undertreated population.

Association of Hormone Therapy with Long-Term Outcomes After Chemoradiation for Locally Advanced Cervical Cancer.

Association of Hormone Therapy with Long-Term Outcomes After Chemoradiation for Locally Advanced Cervical Cancer.

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