Prevalence of 21 Physician-Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study.

Our study reveals that 22.6% of patients with acute lymphoblastic leukemia experienced severe toxicities according to the severe toxicity-free survival endpoint.

The prominence of mental health concerns, osteonecrosis, and various movement disorders highlights the diverse nature of these toxicities.

Given their severity and breadth, ongoing surveillance and intervention should be incorporated into standard care.