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New research · Pulmonology & Critical Care
Scientific reports · 2d
Cohort studyScientific reports · 2026

Comparative outcomes of fentanyl and morphine in critically ill patients with malignancy: a retrospective cohort study utilizing MIMIC-IV.

Huili Shui, Wenqi Huang, Zhenming Xie … Dongxin Tang
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Pulmonology & Critical CareCohort study

Morphine is associated with a lower odds of delirium compared to fentanyl.

Comparative outcomes of fentanyl and morphine in critically ill patients with malignancy: a retrospective cohort study utilizing MIMIC-IV.

Huili Shui et al. · Scientific reports · 2026
Background

Fentanyl and morphine are commonly prescribed opioids for cancer-related pain; however, the comparative associations between these agents and clinical outcomes in critically ill patients with malignancies remain unclear.

Purpose

This study aims to examine the associations of fentanyl versus morphine with delirium, length of stay (LOS) in the intensive care unit (ICU), and short-term mortality in this population.

Results

morphine was associated with a lower risk of delirium compared to fentanyl

OR 0.27 (95% CI 0.20 to 0.37)
null = 10.200.37
CI excludes the null - significant
More results

Secondary outcomes comprised 14- and 30-day all-cause mortality and the LOS in the ICU.

More results

Logistic regression models were adopted to evaluate the association of fentanyl versus morphine with delirium; linear regression models were applied to examine the association with the LOS in the ICU; Cox proportional hazards models were adopted to analyze associations with 14- and 30-day all-cause mortality.

“
Conclusion

These findings indicate potentially divergent outcome associations within this population and may offer a point of reference for individualized analgesic management in critically ill patients with malignancy.

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