Association of cardiovascular-kidney-metabolic syndrome with risk of hip/knee osteoarthritis: A prospective…

Cohort studyMaturitas· Jul 2026

Association of cardiovascular-kidney-metabolic syndrome with risk of hip/knee osteoarthritis: A prospective cohort study.

Zheng Ma, Yixiao Zhang, Liuxin Li … Yuhong Zhao

NephrologyCohort studyPrognosisQ1IF 4.3

High genetic risk and severe CKM syndrome linked to much higher knee osteoarthritis rate.

Association of cardiovascular-kidney-metabolic syndrome with risk of hip/knee osteoarthritis: A prospective cohort study.

Zheng Ma … Yuhong Zhao

Maturitas · Jul 2026

Background

Cardiovascular-kidney-metabolic syndrome reflects the interplay of metabolic, renal, and cardiovascular dysfunction and is linked to adverse health outcomes.

Methods

This prospective cohort study included 256,364 UK Biobank participants free of osteoarthritis at baseline.

Results

high genetic risk and severe CKM syndrome meant a much higher risk of knee arthritis

HR by subgroup · 95% CI

More results

Higher cardiovascular-kidney-metabolic syndrome stages were associated with progressively increased risks of both outcomes.

Associations were stronger in individuals <60 years and differed by sex: hip osteoarthritis risk was greater in men, while knee osteoarthritis risk was greater in women.

More results

A positive additive interaction was observed between genetic susceptibility and cardiovascular-kidney-metabolic syndrome stage.

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Conclusion

Our findings indicate that higher cardiovascular-kidney-metabolic syndrome stages are associated with increased hip/knee osteoarthritis risk, particularly in younger individuals.

Association of cardiovascular-kidney-metabolic syndrome with risk of hip/knee osteoarthritis: A prospective cohort study.

Association of cardiovascular-kidney-metabolic syndrome with risk of hip/knee osteoarthritis: A prospective cohort study.

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