Clinicopathological Correlations, Treatment Response, and Predictors of Outcomes in Childhood Lupus…

Cohort studyInternational journal of rheumatic diseases· Jul 2026

Clinicopathological Correlations, Treatment Response, and Predictors of Outcomes in Childhood Lupus Nephritis in China.

Bai-Xu Sun, Shi-Peng Li, Feng-Qiao Gao … Cai-Feng Li

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NephrologyCohort studyTreatmentQ3IF 1.3

Belimumab is associated with a lower risk of relapse in childhood lupus nephritis.

Clinicopathological Correlations, Treatment Response, and Predictors of Outcomes in Childhood Lupus Nephritis in China.

Bai-Xu Sun … Cai-Feng Li

International journal of rheumatic diseases · Jul 2026

Purpose

To investigate clinicopathological correlations, treatment responses, and predictors of outcomes in childhood lupus nephritis (cLN).

Methods

Retrospective cohort study of 71 biopsy-proven cLN patients at Beijing Children's Hospital (2005-2024).

n = 71 biopsy-proven cLN patients

OR = 0.220

Results

OR = 0.220

belimumab was linked to a lower chance of lupus kidney disease symptoms returning

n = 71 biopsy-proven cLN patients

More results

Over a median 40-month follow-up, 69.1% were female (mean onset age 10.0 ± 2.3 years).

Complete renal remission (complete renal remission) was achieved in 92.8% (mean 13.4 months); 26.6% experienced relapse.

Higher CI predicted lower likelihood of achieving LLDAS (OR = 1.425, p = 0.042).

More results

CKD developed in 4.3%; mortality was 1.4%.

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Conclusion · 1 of 2

Modern treatment yields favorable outcomes for cLN. Baseline disease activity, hypocomplementemia, and histological activity index predict treatment response.

Conclusion · 2 of 2

activity index and CI demonstrate distinct associations with acute and chronic injury. Belimumab offers significant advantages in relapse prevention and glucocorticoid reduction.

Clinicopathological Correlations, Treatment Response, and Predictors of Outcomes in Childhood Lupus Nephritis in China.

Clinicopathological Correlations, Treatment Response, and Predictors of Outcomes in Childhood Lupus Nephritis in China.

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