IgG N-Glycosylation and Incident Neuropathy and Nephropathy in People With Type 2 Diabetes: A Pooled… | ScholarDeck

Paper

IgG N-Glycosylation and Incident Neuropathy and Nephropathy in People With Type 2 Diabetes: A Pooled Analysis of Prospective Cohort Studies.

New research · Internal Medicine

Diabetes care · 1mo

Cohort studyDiabetes care· Jul 2026

IgG N-Glycosylation and Incident Neuropathy and Nephropathy in People With Type 2 Diabetes: A Pooled Analysis of Prospective Cohort Studies.

Cecilia Martinez Escobedo, Anna Birukov, Ralph Heijmans … Clemens Wittenbecher

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EndocrinologyCohort studyPrognosisQ1IF 15.8

Agalactosylated IgG N-glycans are associated with higher diabetic nephropathy risk.

IgG N-Glycosylation and Incident Neuropathy and Nephropathy in People With Type 2 Diabetes: A Pooled Analysis of Prospective Cohort Studies.

Cecilia Martinez Escobedo … Clemens Wittenbecher

Diabetes care · Jul 2026 · Q1 in Internal Medicine

Purpose

To examine whether IgG N-glycosylation patterns are prospectively associated with incident diabetic nephropathy and neuropathy.

Methods

We analyzed IgG N-glycosylation profiles in four cohorts: EPIC-Potsdam, DiaGene, GenoDiabMar, and Hoorn DCS.

n = 3,263 individuals

Results

more agalactosylated sugar chains on antibodies means higher kidney damage risk

HR 1.13 (95% CI 1.04 to 1.24)

CI excludes the null - significant

More results

Associations of IgG-GPs with incident neuropathy were rendered nonsignificant after multiple testing correction.

“

Conclusion

IgG N-glycosylation may reflect immune-related mechanisms relevant to diabetic nephropathy; but the evidence between IgG-GPs and diabetic neuropathy remains inconclusive.

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