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New research · Hematology
Journal of cardiothoracic surgery · 2d
Cohort studyJournal of cardiothoracic surgery · 2026

Predictive value of preoperative hematologic inflammation indices (NLR, PLR, SII) and clinical risk factors in predicting postoperative pulmonary complications after elective isolated on-pump coronary artery bypass grafting: a retrospective cohort study of 1034 patients.

Özden Vezir, Esra Ertürk Tekin
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HematologyCohort study

Preoperative NLR shows excellent ability to predict pulmonary complications after bypass surgery.

Predictive value of preoperative hematologic inflammation indices (NLR, PLR, SII) and clinical risk factors in predicting postoperative pulmonary complications after elective isolated on-pump coronary artery bypass grafting: a retrospective cohort study of 1034 patients.

Özden Vezir et al. · Journal of cardiothoracic surgery · 2026
Background

Pulmonary complications after coronary artery bypass surgery continue to be a significant problem, affecting 5-20% of patients, prolonging hospital stays and increasing costs.

Methods

The records of 1034 patients who underwent elective coronary artery bypass grafting with heart-lung machine support between 2023 and 2024 were retrospectively reviewed.

n = 1034 patients
AUC 0.939
Results
NLR is excellent at predicting who will get lung problems after bypass surgery
n = 1034 patients
More results

114 patients (11%) developed PPC.

PLR and SII also reached statistical significance, but with effect sizes very close to unity (adjusted OR 1.02 and 1.01 respectively), indicating that they offered minimal additional discriminatory value once NLR was taken into account.

“
Conclusion · 1 of 2

In this single-center retrospective cohort, preoperative NLR, PLR and SII were associated with PPC, with NLR accounting for most of the predictive signal.

Conclusion · 2 of 2

Because they are measured at a single preoperative timepoint, these indices reflect baseline inflammatory tone and cannot capture the acute, surgery-induced inflammatory response that drives postoperative pulmonary complications.

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