Prognostic determinants of overall, disease-specific and recurrence-free survival in cutaneous squamous cell…

Cohort studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery· Sep 2026

Prognostic determinants of overall, disease-specific and recurrence-free survival in cutaneous squamous cell carcinoma of the head and neck: a single-centre retrospective cohort study.

Mustafa Aktaş, Senem Çengel Kurnaz, Emre Demirel … Mehmet Çelebi

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Skin Cancer & MelanomaCohort studyPrognosisQ2IF 2.5

Positive surgical margins, perineural invasion and nodal stage were each independently associated with worse survival in head and neck cutaneous squamous cell carcinoma.

Prognostic determinants of overall, disease-specific and recurrence-free survival in cutaneous squamous cell carcinoma of the head and neck: a single-centre retrospective cohort study.

Mustafa Aktaş … Mehmet Çelebi

European archives of oto-rhino-laryngology · Sep 2026 · Q2 in General Medicine

Purpose

To identify the independent prognostic determinants of overall, disease-specific and recurrence-free survival in cutaneous squamous cell carcinoma (cSCC) of the head and neck in a single-centre cohort.

Methods

Eighty patients who underwent surgery for head and neck cSCC between January 2008 and January 2023 were reviewed retrospectively.

n = 47 patients

Results

perineural invasion made death from the disease about five times as likely, after adjustment

AHR 1.06 (95% CI 1.03 to 1.09)

null 1

1.03

1.09

CI excludes the null - significant

More results

Mean age was 71.3 years; 85% were male.

In pre-specified multivariable models, surgical margin, perineural invasion and nodal stage were independent determinants of all three endpoints.

Older age was independent for overall survival only (aHR 1.06; 95% CI 1.03-1.09).

More results

The proportional-hazards assumption held, and on internal validation the optimism-corrected c-index remained high (0.74-0.85).

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Conclusion

Surgical margin status, perineural invasion and nodal stage were consistent, independent determinants of prognosis that identify high-risk patients; clear margins and accurate nodal assessment should be prioritised, though the retrospective design precludes causal inference.

Prognostic determinants of overall, disease-specific and recurrence-free survival in cutaneous squamous cell carcinoma of the head and neck: a single-centre retrospective cohort study.

Prognostic determinants of overall, disease-specific and recurrence-free survival in cutaneous squamous cell carcinoma of the head and neck: a single-centre retrospective cohort study.

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