Mohs Micrographic Surgery for Penile Squamous Cell Carcinoma: A Systematic Review.

Systematic reviewDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]· Oct 2026

Mohs Micrographic Surgery for Penile Squamous Cell Carcinoma: A Systematic Review.

Jonathan D Greenzaid, Ainsley J Ruley, Kelly M Kimball … Kathryn T Shahwan

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Dermatologic SurgerySystematic reviewTreatmentQ2IF 1.2

Mohs micrographic surgery for penile squamous cell carcinoma had rare local recurrence across 329 tumors in 19 studies.

Mohs Micrographic Surgery for Penile Squamous Cell Carcinoma: A Systematic Review.

Jonathan D Greenzaid … Kathryn T Shahwan

Dermatologic surgery · Oct 2026 · Q2 in Dermatology

Background

Squamous cell carcinomas (squamous cell carcinomas) of the penis are often treated with partial or total penectomy.

Purpose

This study systematically reviews clinical studies on mohs micrographic surgery for penile squamous cell carcinomas, summarizing disease outcomes and surgical complications.

Methods

A systematic review was conducted using Ovid MEDLINE, Embase, Cochrane, CINAHL, and Web of Science for studies published through October 23, 2024.

n = 15,

Results

of tumors recurred locally after Mohs surgery, so recurrence was uncommon, with a higher rate in advanced stages

8%

Local recurrence, T2/T

1%

Local recurrence, Tis/

More results

Nineteen studies with 329 penile squamous cell carcinomas met inclusion criteria.

Urologic Surgery collaboration was utilized in 27% of cases, performing procedures including urethrectomy, meatotomy, and reconstruction.

More results

Complications occurred in 9%, including poor wound healing ( n = 11, 3%), urethral stricture ( n = 11, 3%), wound infection ( n = 3, 1%), and bleeding ( n = 2, 1%).

“

Conclusion · 1 of 2

Mohs micrographic surgery is a penis-sparing surgical approach with low recurrence rates in low-stage tumors.

Conclusion · 2 of 2

Multidisciplinary collaboration with Urology is recommended in cases of advanced-stage tumors, anticipated reconstruction, or urethral involvement. Further research is needed, as the level of evidence was low in this systematic review.

Mohs Micrographic Surgery for Penile Squamous Cell Carcinoma: A Systematic Review.

Mohs Micrographic Surgery for Penile Squamous Cell Carcinoma: A Systematic Review.

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