[⁶⁸Ga]Ga-CTR-FAPI versus [⁶⁸Ga]Ga-FAPI-04 PET/CT for patient evaluation in radioiodine-refractory differentiated thyroid cancer: A prospective comparative study.

Of the 40 enrolled patients, 37 had detectable metastatic lesions on both imaging modalities.

Two patients had lesions exclusively detected by [⁶⁸Ga]Ga-CTR-FAPI PET/CT. [⁶⁸Ga]Ga-CTR-FAPI PET/CT achieved superior visual detection performance in 17.5% (7/40) of patients (p = 0.016) concerning lesion distribution areas.

Furthermore, [⁶⁸Ga]Ga-CTR-FAPI PET/CT exhibited additional cerebral and hepatic metastatic lesions as well as higher tracer uptake in shared lesions located at brain (n = 1), liver(n = 2) and kidney (n = 1), while the only mediastinal soft tissue metastasis showed an SUV max slightly higher in [⁶⁸Ga]Ga-FAPI-04 PET/CT.